MICKI–Microscopy Imaging Core of the Krasnow Institute

Just opened in our new space. Our cellular imaging core. The facility is already being used extensively by several of our neuroscience labs, but it’s available for other interested investigators in the Washington D.C. area and includes confocal microscopy.

Cellular imaging is a complement to our existing non-invasive human brain imaging capabilities here at Krasnow. In my own research, I’ve used confocal microscopy to image in vivo, the translocation of protein kinase C following sea urchin egg fertilization. Here at Krasnow, cellular imaging is used for a variety of neuroscience models ranging from drosophila (fruit fly) to mouse.

For those interested in using MICKI, please just drop me a line.

Cellular imaging at Krasnow


I’m pleased to report that we’ve taken delivery of our Nikon C1 confocal microscope and that very shortly we’ll be opening a cellular imaging core at the Institute to complement our MRI facility.

So what’s the deal with confocal microscopy? The short version goes like this: biological specimens, especially living tissue ones, are thick. Classical microscopes have a problem with this and internal organelles get blurred out. With confocal microscopy, we can get around that problem and look into the sample with all the detail of the cell’s three-dimensional structure preserved. Used in consort with our ability to molecularly engineer biological components of the cell to fluoresce, this becomes an incredibly powerful tool for our neuroscientists who work at the neuronal or cellular level.